Taking a series of steel round spring of a fast metro vehicle as the research object, the fatigue life prediction analysis was carried out. The finite element model was established by using finite element analysis software ANSYS, and the stress analysis under the maximum working load was carried out. The dynamic simulation software SIMPACK was used to establish the dynamic model of the fast metro vehicle, and the longitudinal, lateral and vertical vibration displacements with time of the spring were analyzed. Using the fatigue cumulative damage theory, taking the spring stress and load spectrum as the input, based on the fatigue life special simulation software FE-SAFE, the fatigue life of the spring was analyzed. The results show that the inner side of the second ring of the fast metro vehicle is the most stressful part, the maximum stress is 1 294.19 MPa, and the fatigue life is about 1 945 924 times, which is in line with the actual situation of a series of steel round springs of a fast metro vehicle.