Machine vision technology has brought profound changes to traditional industry. Fast calibration with machine vision of the parallel robot fetching system is studied. The rapid calibration of the system was mainly included of the camera calibration and the man-machine (camera and robots) calibration. The hardware of calibration device was adopted of Germany Basler series Ace industrial camera and a Delta Robot body. Camera calibration software using C# programming tools by calling the image processing software HALCON function library development of image processing software, the calibration of the camera was achieved. Man-machine calibration using the open software platform CODESYS has developed a robot eye calibration transformation module. The experimental results show that the calibration method is convenient, reliable and stable.