The simulation model of urethral valve was established based on Fluent software, the driving pressure in the urethral valve was numerically simulated using the computational model of turbulent κ-ε, and the influence of the structure and ultrasonic controlling parameters of urethral valve on the driving performance was analyzed. The results show that the opening time of urethral valve is shortened and the driving performance of urethral valve is improved by reducing the volume of driving cavity, increasing ultrasonic intensity, radiation area and frequency. The simulation model is effective and practical, which can provide the theoretical guidance for the driving performance analysis and optimization design of urethra valve. 