Based on the analysis of the structure and working principle, a simulation model was established using AMESim to address the issue of low dynamic response of pneumatic pilot valves. The effects of main valve spring stiffness, spring preload, air source pressure, and throttle hole size on the dynamic response of the pilot valve were studied through parameterized simulation. The results showed that the influence of each influencing parameter on the dynamic response characteristics was different, and it was difficult to obtain the optimal solution by adjusting a certain parameter. On the basis of parameterized simulation analysis, a multi parameter optimization simulation was conducted based on SimV&Ver Math. The optimal solution was obtained using Bayesian+quasi Newton optimization algorithm, which reduced the total response time of the pneumatic pilot valve by 7.2ms. The correctness of the simulation analysis was verified through experiments.