The column of the mineral direct-drive turning-milling compound center is generally a solid structure,which has problems such as heavy structure,material waste,and high manufacturing cost.Taking the CXK80 mineral material column as the research object,the dynamic and static performance analysis and heat transfer analysis were carried out.Then,reducing the weight of the mineral material column,improving its strength and stiffness were set as optimization objectives.The topology optimization and multi-objective dimension optimization based on genetic algorithm were used for lightweight design.The simulation results show that the weight of the optimized mineral material column is reduced by 14.2%,the temperature on the guide rail embedding surface is decreased by 21%,and the first two modal frequencies of the column are correspondingly improved.To verify the effectiveness of the simulation analysis,modal hammer impact experiments were conducted.The experimental data and simulation data are basically consistent with an error within 3%,achieving the goal of reducing the weight of the mineral material column and saving manufacturing costs.