Aiming at the problems of low efficiency and high operation risk of offline program inspection methods in the automated manufacturing process of largescale aircraft components, an automatic manufacturing simulation platform based on the secondary development of RobotStudio was built as an offline simulation tool. The virtual hybrid control system integrated with ABB controller and numerical control system and the physical model of the equipment were built in the simulation platform to realize the unification of the structure parameters, motion control parameters of the simulation system and the actual automation system. The calculation module of aircraft position and posture, compilation module of track and robot motion program were both developed based on C# and RobotStudio API to realize the rapid transformation of largescale aircraft components posture and automatic program compilation. Aircraft profile scanning was used as an application scene for testing. The results show that the guide rail and robot in the simulation platform move in the same way as the actual automation system; through this platform, the structure collision check and program correctness check can be realized, the program check time before automatic operation can be reduced and the safety performance of the automation system can be improved.